Sinclair Method Studies
Published on: 11/06/2025
This article examines the scientific foundation behind TSM, drawing on nearly three decades of peer‑reviewed trials, neuroimaging research, and systematic reviews.
Why Is It So Difficult to Stop Drinking? The Science Behind Endorphins and Incomplete Treatment
Bruce Rose Published on: 27/05/2025
Many of us assume that stopping drinking is simply about self-control. But if you've ever tried to cut down—or stop entirely—you'll know it's not that simple. It often feels like you're fighting your own brain. And in many ways, that’s exactly what’s happening.
The Sinclair Method (TSM)
Does The Sinclair Method Work? Evidence, Success Rates & What to Expect
Bruce Rose Published on: 22/05/2025
The Sinclair Method (TSM) is a medically supervised treatment for Alcohol Use Disorder (AUD) that utilises the opioid-blocking medication naltrexone. This treatment works by weakening the association between alcohol and the brain’s reward system. Naltrexone is taken one hour before drinking, blocking endorphins that would normally reinforce the behaviour.
The Sinclair Method (TSM)
Alcohol Statistics in the UK: 25 Years of Change, Challenge and Hope
Bruce Rose Published on: 20/05/2025
Over the past 25 years, alcohol consumption in the UK has undergone significant transformation. While public health campaigns have increased awareness, the statistics paint a complex picture of progress, stagnation, and new challenges.
The Sinclair Method (TSM)
When Is Drinking Out of Control? Spotting the Signs Before It’s Too Late
Bruce Rose Published on: 15/05/2025
Alcohol can start off as a way to relax, celebrate, or socialise. But over time, that relationship can shift—sometimes subtly, sometimes dramatically. Out of control drinking isn’t always obvious. It can creep into your routines, habits, and mental health without you noticing until real damage has been done.
The Sinclair Method (TSM)
